Increased Levels of Leukocyte Elastase in Ischemic Stroke and in Subjects with Vascular Risk Factors

Abstract
Proteolytic enzymes by polymorphonuclear leukocytes such as elastase may contribute to the pathogenesis of acute cerebral ischemia. We measured elastase α1-protease inhibitor complexes (EIC) in acute ischemic stroke and in controls with and without vascular risk factors. Levels of EIC were higher in patients (n = 24, 51.4 ± 18.5 ng/ml) than in healthy controls (n = 26, 36.2 ± 11.5 ng/ml, p

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