Effect of Supplements with Bifidobacterium longum and Lactobacillus acidophilus on the Intestinal Microbiota during Administration of Clindamycin

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Abstract
Thirty healthy volunteers in three groups participated in a study of the influence of supplements containing Bifidobacterium longum and Lactobacillus acidophilus on the intestinal microbiota during administration of clindamycin. All groups received clindamycin perorally q.d.s. for 7d. Group I also received a supplement with B. longum and L. acidophilus, group II received a supplement with B. longum and group III received a placebo, for 21 d. The numbers of anaerobic microorganisms decreased in all groups, but the reduction of bacteroides was significantly smaller in group I than in group III (PPP<0·05).