1-Phenyl-3-(aminomethyl)pyrroles as Potential Antipsychotic Agents. Synthesis and Dopamine Receptor Binding
- 1 December 1995
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 38 (25) , 4950-4952
- https://doi.org/10.1021/jm00025a013
Abstract
A series of 1-phenyl-3-(aminomethyl)pyrroles were prepared in two steps from aniline and their affinities for D2, D3, and D4 dopamine receptor subtypes determined. A 15-fold selectivity for cloned human D4 receptors over cloned African Green monkey D2 receptors was observed with 1-(2-pyridyl)-4-[[3-(1-phenylpyrrolyl)]methyl]piperazine.Keywords
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