The Neurotoxicity of the Rat Poison Vacor
- 10 January 1980
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 302 (2) , 73-77
- https://doi.org/10.1056/nejm198001103020202
Abstract
Oral ingestion of a new rat poison that antagonizes nicotinamide metabolism, N-3-pyridylmethyl-N′-p-nitrophenyl urea (PNU, Vacor), is known to cause diabetes mellitus. I describe neurologic complications of PNU ingestion in 12 patients 19 to 50 years of age who swallowed between 0.39 and 7.02 g of PNU. One died within a day, and five died of chronic complications 40 to 182 days after taking the poison.This publication has 10 references indexed in Scilit:
- Diabetes mellitus and neuropathy following Vacor ingestion in manArchives of internal medicine (1960), 1979
- TREATMENT OF IDIOPATHIC ORTHOSTATIC HYPOTENSION (SHY-DRAGER SYNDROME) WITH INDOMETHACINThe Lancet, 1978
- Diabetes mellitus following rodenticide ingestion in manJAMA, 1978
- Diabetes Mellitus and Autonomic Dysfunction After Vacor Rodenticide IngestionDiabetes Care, 1978
- The Sympathetic-Nervous-System Defect in Primary Orthostatic HypotensionNew England Journal of Medicine, 1977
- Norepinephrine Depletion in Idiopathic Orthostatic HypotensionAnnals of Internal Medicine, 1975
- Hepatic Toxicity from Large Doses of Vitamin B3(Nicotinamide)New England Journal of Medicine, 1973
- Etilefrine in the Treatment of Levodopa-Induced Orthostatic HypotensionArchives of Neurology, 1973