Resistance of a Pyrimethamine-Resistant Strain of Plasmodium gallinaceum to Certain 2,4-Diaminopyrimidines and Relatad Compounds
- 1 August 1954
- journal article
- research article
- Published by JSTOR in Journal of Parasitology
- Vol. 40 (4) , 472-475
- https://doi.org/10.2307/3273901
Abstract
Seven diaminopyrimidines (including pyrimethamine), chlorguanide, and a diaminotriazine were tested against a pyrimethamine-resistant strain of P. gallinaceum. The strain was 64-fold resistant to pyrimethamine. It showed relatively little resistance (2-fold) to some chemically related compounds and marked cross-resistance (64- to 512-fold) to others. It was about 16-fold resistant to chlorguanide and 8-fold resistant to a diaminotriazine related to chlorguanide.This publication has 3 references indexed in Scilit:
- THE ANTIMALARIAL PROPERTIES OF 2,4-DIAMINO-5-PARA-CHLOROPHENYL-6-ETHYLPYRIMIDINE (DARAPRIM)1953
- Acquired resistance to proguanil in Plasmodium knowlesiTransactions of the Royal Society of Tropical Medicine and Hygiene, 1952
- Effect of 2,4-diamino-5-(p-chlorophenoxy)-6-methylpyrimidine and 2,4-diamino-6,7-diphenylpteridine on Chlorguanide-resistant Strain of Plasmodium gallinaceumExperimental Biology and Medicine, 1951