PRODUCTION OF PRIMATE D-TYPE VIRUS INTERSPECIES-SPECIFIC ANTIGEN DURING COCULTIVATION OF HUMAN-BREAST FIBROADENOMA CELLS WITH BAT LUNG-CELLS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 50  (8) , 743-746
Abstract
Nine human breast fibroadenomas, initially negative for D-type retrovirus interspecies-specific antigen, do not produce that antigen during 6 mo. of cocultivation with bat (Tadarida brasiliensis) lung NBL-12 cells. Of 5 human breast fibroadenomas already positive for D-type virus interspecies-specific antigen before cultivation, 3 induced a transient D-type retrovirus interspecies-specific antigen production after 3-4 mo. of cocultivation with bat lung cells. The antigen is detectable both in cocultivated cells and in pellets sedimented from the coculture fluid. D-type retroviruses are apparently associated with human breast fibroadenomas.

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