Studies on the syntheses of heterocyclic compounds. Part DCXXII. Total synthesis of (±)-mappicine [7-(1-hydroxypropyl)-8-methyl-indolizino[1,2-b]quinolin-9(11H)-one]
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 18,p. 1825-1828
- https://doi.org/10.1039/p19750001825
Abstract
Methyl 9,11-dihydro-9-oxoindolizino[1,2-b]quinoline-7-carboxylate (4) was converted into its 8-methyl derivative (5), reduction of which gave 7-hydroxymethyl-8-methylindolizino[1,2-b]quinolin-9(11H)-one (9). This was converted into (±)-mappicine (1) by way of the 7-carbaldehyde (13) and the 7-propionyl derivative (14).Keywords
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