p53 intron 7 polymorphisms in urinary bladder cancer patients and controls
Open Access
- 1 January 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 15 (1) , 57-60
- https://doi.org/10.1093/mutage/15.1.57
Abstract
A C→T polymorphism in intron 7 of the human tumour suppressor gene p53 was studied in 159 urinary bladder cancer patients and 171 non-cancer controls. The polymorphism was found in 15% of both patients and controls, suggesting that it has no relevance in urinary bladder cancer pathogenesis or aetiology. A second polymorphism, a T→G change located 20 bp downstream of the C→T change, was found in all samples with the C→T change. Our findings indicate that the C→T and the T→G changes occur simultaneously and belong to the same allelotype.Keywords
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