Excitotoxin lesion of nucleus basalis causes a specific decrease in Go mRNA in cerebral cortex
- 29 October 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 273 (1-2) , 63-67
- https://doi.org/10.1016/0014-5793(90)81051-o
Abstract
Lesions of the ascending cholinergic pathway from nucleus basalis are known to have profound effects on cortical function. In particular, a substantial potentiation of carbachol‐stimulated polyphosphoinositide turnover is detected from 1 day after lesion and is maintained for several days before returning to normal by 1 month. In this study the effect of this lesion was investigated on levels of three G‐protein α‐subunit mRNAs. Excitotoxin lesion of the nucleus basalis caused a selective reduction in the levels of Goα mRNA in cerebral cortex ipsilateral to the lesion, G5α and Giα mRNA being unaffected. The maximal effect was obtained at 3 days after lesion where levels of Goα mRNA were decreased by 40% compared to sham‐operated animals. Levels of Goα mRNA returned to normal values by 28 days. Treatment with MK‐801 caused a significant attenuation of the decrease in Goα mRNA, indicating the involvement of NMDA receptors in this response.Keywords
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