Transport of cations by rabbit gall bladder: evidence suggesting a common cation pump

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Abstract
Rabbit gall bladders were excised, everted, and placed (empty) in oxygenated buffered solutions containing Na K, Li, Ma, Ca, and labeled rubidium, cesium, and strontium. After 0.5-8 hr., the fluid which appeared within the everted sac was sampled. In the presence of reasonably normal cation concentrations (except for Li 4 mM) and 0-120 mM sucrose, all 8 cations appeared in the fluid at serosal/mucosal ratios which increased in parallel with increasing sucrose addition. Cations with crystal radii larger or smaller than Na exhibited ratios lower than Na. When 5/8 of the Na was replaced by any one of the other cations, the fluids elaborated contained as much of the substituted cation as of Na. Some transport persisted in the virtual absence of Na. The results favor a common cation transport mechanism, although passive movement in response to Na transport, or independent mechanisms for each of the 7 other ions cannot be excluded.

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