Reactions from the Use of Benzodioxane (933 F) in Diagnosis of Pheochromocytoma

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Abstract
PHEOCHROMOCYTOMA is a known cause of hypertension that is being more frequently diagnosed.1 This tumor produces epinephrine or an epinephrine-like substance that is responsible for the observed increase in blood pressure. Pharmacologically the dioxane group of drugs (883 F, 933 F, 1164 F and others) prevent or reverse the hypertension produced by epinephrine in animal experiments.2 , 3 The compounds 883 F and 933 F do not have any significant effect on the blood pressure of dogs or rats with renal hypertension.4, 5 Thus, the benzodioxane group of drugs would be expected to prevent the effects of circulating epinephrine produced by a pheochromocytoma, . . .