Increased Glucagon Secretion in Protein-fed Rats: Effects of Refeeding a Normal Diet

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Abstract
The length of time was investigated, which was required for elevated glucagon secretion induced by protein feeding to be reversed upon resumption of a normal diet. Portal vein (PV) glucagon and glucagon secretion by isolated islets stimulated with arginine were determined in rats fed a high protein (HP) diet for 1 wk, in control rats and in animals fed the HP diet for 1 wk followed by the control regimen for 1, 2, 3, 5 or 7 days. Protein feeding caused a 500% rise of PV glucagon which was not reversed until day 7 on the control food. Arginine stimulated glucagon secretion by isolated islets which was almost doubled by protein feeding, returned to basal level on the 5th day of refeeding the control diet. A slow change in the rate of glucagon synthesis was demonstrated.