The secondary alcohol metabolite of doxorubicin irreversibly inactivates aconitase/iron regulatory protein‐1 in cytosolic fractions from human myocardium
- 1 May 1998
- journal article
- Published by Wiley in The FASEB Journal
- Vol. 12 (7) , 541-552
- https://doi.org/10.1096/fasebj.12.7.541
Abstract
Anticancer therapy with doxorubicin (DOX) is limited by severe cardiotoxicity, presumably reflecting the intramyocardial formation of drug metabolites that alter cell constituents and functions. In...Keywords
Funding Information
- Consiglio Nazionale delle Ricerche
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