Renal dehydropeptidase-I stability of LJC 10,627, a new carbapenem antibiotic
- 1 February 1992
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 36 (2) , 481-483
- https://doi.org/10.1128/aac.36.2.481
Abstract
LJC 10,627 is a new parenteral carbapenem antibiotic. LJC 10,627 stability against human renal dehydropeptidase-I was compared with that of imipenem. Hydrolysis of this compound was not detectable by spectrophotometrical assay. Even after a 2-h incubation of antibiotics with this enzyme at 30 degrees C, the concentration of LJC 10,627 remained at 92.3% of the initial concentration, whereas imipenem completely disappeared. Thus, it was found that this compound was highly stable against human renal dehydropeptidase-I. Furthermore, LJC 10,627 had a low affinity for this enzyme, as indicated by the high Ki value (0.38 mM).Keywords
This publication has 8 references indexed in Scilit:
- In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase IAntimicrobial Agents and Chemotherapy, 1990
- In vitro activity and beta-lactamase stability of a new carbapenem, SM-7338Antimicrobial Agents and Chemotherapy, 1989
- In vitro activity against aerobic and anaerobic gram-positive and gram-negative bacteria and beta-lactamase stability of RS-533, a novel carbapenemAntimicrobial Agents and Chemotherapy, 1986
- In vitro and pharmacokinetic properties of the carbapenemsAntimicrobial Agents and Chemotherapy, 1986
- Carbapenems, a new class of beta-lactam antibioticsThe American Journal of Medicine, 1985
- In-vitro and in-vivo antibacterial activity of imipenem against clinical isolates of bacteriaJournal of Antimicrobial Chemotherapy, 1983
- Metabolism of Thienamycin and Related Carbapenem Antibiotics by the Renal Dipeptidase, Dehydropeptidase-IAntimicrobial Agents and Chemotherapy, 1982
- A spectrophotometric assay of β-lactamase action on penicillinsBiochemical Journal, 1974