HORMONAL EFFECTS ON SULFANILAMIDE ACETYLATION12

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Abstract
EVIDENCE is accumulating which indicates that hormones influence coenzyme A dependent reactions. Androgens and adrenocorticoids in some cases have been shown to affect the synthesis of citric acid in various organs under in vivo (2, 3) and in vitro (4, 5, 6) conditions. Fatty acid and acetoacetate synthesis from acetate appear to be under hormonal control (4, 7, 8). Hormonal effects on p-aminobenzoic acid acetylation (9) and choline acetylation (10, 11, 12, 13) have also been described. Little insight into the manner in which these effects are exerted has been obtained. This study was undertaken to explore the possibility that sulfanilamide acetylation could be a mirror reflecting hormonal influences on coenzyme A dependent reactions.