Alteration of the p14 ARF gene and p53 status in human hepatocellular carcinomas

1 April 2004

journal article
research article
Published by Springer Nature in The Esophagus

Vol. 39 (4) , 355-361
https://doi.org/10.1007/s00535-003-1302-9

Abstract

The INK4a/ARF locus encodes p16^INK4a and p14^ARF, both of which are crucial for two tumor suppressor pathways, retinoblastoma (RB)/p16^INK4a and p53/ARF. Inactivation of RB/p16^INK4a was frequently reported, but alterations of the p14 ^ARF gene in hepatocellular carcinoma (HCC) in the Japanese population have been insufficiently analyzed.

Keywords

P14ARF
P53
INK4A/ARF LOCUS
HEPATOCELLULAR CARCINOMA

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