HAEMODYNAMICS AND MYOCARDIAL OXYGEN CONSUMPTION DURING ISOFLURANE (FORANE) ANAESTHESIA IN GERIATRIC PATIENTS
Open Access
- 1 July 1976
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 48 (7) , 669-675
- https://doi.org/10.1093/bja/48.7.669
Abstract
The influence of isoflurane on haemodynamics and myocardial oxygen consumption was examined in seven geriatric patients under conditions of controlled ventilation and a normal arterial carbon dioxide tension. During isoflurane/nitrous oxide in oxygen anaesthesia (0.75 and 1.5 vol% inspired isoflurane) no significant changes occurred in cardiac output, stroke volume, heart rate, central venous and pulmonary artery pressure. Arterial pressure decreased, as did total peripheral resistance. A reduction in left ventricular maximum dp/dr (18-39%) was, at least in part, a result of changes in loading conditions. Total body (Cao2−Cvo2) and base excess values remained within the normal range. We consider that the oxygen supply was adequate to meet the metabolic demands of the body as a whole. Myocardial oxygen consumption decreased by 25% during 0.75 vol% inspired isoflurane and by 43.5% with deepening of anaesthesia (1.5 vol% isoflurane).Keywords
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