Nitric oxide and cell proliferation
- 16 May 2006
- journal article
- Published by Wiley in The FEBS Journal
- Vol. 273 (11) , 2329-2344
- https://doi.org/10.1111/j.1742-4658.2006.05250.x
Abstract
Nitric oxide (NO•) has been proposed to be a physiological modulator of cell proliferation, able to promote in most cases cell cycle arrest. In this review I explore the molecular basis of this mechanism of action. The modulatory action of NO•on the intracellular concentration of cGMP and the machinery directly involved in the control of cell cycle progression, including the expression and activity of diverse cyclins and cyclin‐dependent kinases, their physiological inhibitors, and the master transcriptional regulator retinoblastoma protein, will be discussed. The role of NO•in proliferation mediated by tyrosine kinase receptors such as the epidermal growth factor receptor and downstream signalling pathways will also be considered. Finally, the involvement of NO•in proliferative processes relevant for normal development will be outlined.Keywords
This publication has 116 references indexed in Scilit:
- Effects of IGF-II on promoting proliferation and regulating nitric oxide synthase gene expression in mouse osteoblast-like cellJournal of Zhejiang University SCIENCE, 2005
- Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cellsCell Biology and Toxicology, 2005
- Position in Cell Cycle Controls the Sensitivity of Colon Cancer Cells to Nitric Oxide-Dependent Programmed Cell DeathCancer Research, 2004
- Endogenous Production of Nitric Oxide by Vascular Endothelial Growth Factor Down-Regulates Proliferation of Choriocarcinoma CellsBiochemical and Biophysical Research Communications, 2001
- Nitric oxide mediates either proliferation or cell death in cardiomyocytes. Involvement of polyaminesAmino Acids, 1999
- Does Nitric Oxide Regulate Smooth Muscle Cell Proliferation?Journal of Vascular Research, 1998
- Counter-Regulation of T Helper 1 Cell Proliferation by Nitric Oxide and Interleukin-2Biochemical and Biophysical Research Communications, 1997
- Exogenous Nitric Oxide Inhibits Proliferation of Cultured Vascular Endothelial CellsBiochemical and Biophysical Research Communications, 1994
- Interferon-γ inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generationBiochemical and Biophysical Research Communications, 1992
- Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALBc 3T3 fibroblasts by a cyclic GMP-independent mechanismBiochemical and Biophysical Research Communications, 1990