CYTOTOXIC T LYMPHOCYTE RECOGNITION OF HYBRID MHC CLASS I MOLECULES
- 1 October 1988
- journal article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 15 (5-6) , 295-305
- https://doi.org/10.1111/j.1744-313x.1988.tb00433.x
Abstract
We have utilized a group of MHC class I genes produced by in vitro recombination between Dp and Dd to study recognition of MHC class I molecules by cytolytic T cells (CTLs). Both polyclonal allo-specific and H-2-restricted CTLs require that alpha 1 and alpha 2 of the target class I molecule be derived from the same haplotype for efficient killing. By using T-cell lines we showed that within the bulk population there must exist a fraction of T cells which can recognize epitopes in alpha 1 or alpha 2. Critical residues for T-cell recognition have been identified using these chimeric genes.Keywords
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