Neuere Erkenntnisse zur Regulation des Sekundärstoffwechsels von Streptomyceten

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Abstract
A survey is given summarizing recent insights into the causes of the genetic segregation of antibiotic‐producingStreptomycesstrains (plasmids, transposons, reiterated gene sequences, direct and inverted repeats). Referring to the classical regulatory models of prokaryotic operons, similar regulatory principles were shown to be involved in the secondary metabolism (pab‐gene ofS. griseus, brp‐gene ofS. hygroscopicus, afs B‐gene and A‐factor ofS. griseus) and the known features of its control by catabolites as well. The heterogeneity of the transcriptional system (multiple promotors and holoenzymes of the RNA polymerase) is shown to constitute an essential element of the secondary metabolism accomplishing its integration into cellular cytodifferentiation.