Role of Drugs in Production of Gastroduodenal Ulcer

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Abstract
INDISPUTABLE EVIDENCE of a cause-and-effect relation between drugs and gastroduodenal ulceration is difficult to obtain because a number of variables influence the incidence of ulceration.1 However, certain drugs have been suspected of ulcerogenic potentiality because of the following circumstantial evidence: the experimental production of ulcer in animals, the demonstration of a drug effect on a mechanism suspected of participating in the pathogenesis of ulcer, a close temporal relationship between the onset of drug administration and manifestation of ulcer de novo, or reactivation of peptic ulcer and the incidence of ulceration during drug therapy in one group of patients compared with a control group not receiving the drug in question. A drug's ulcerogenic potentiality may result from its excessive stimulation of gastric secretion, its interference with mucosal resistance, or both. Although vascular congestion and stasis with reduced vitality in local mucosal areas probably contribute to the pathogenesis, prolonged contact of