Feeding Experiments with Precursors of Tropane Alkaloids Using Suspension Cultures of Atropa belladonna.

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Abstract
Feeding experiments have been carried out with alkaloid precursors (hygrine, tropinone and tropic acid) using suspension cultures of Atropa belladonna to study the transport of these compounds into the cells, stimulation of alkaloid synthesis, and possible repressed steps in their biosynthesis. Both hygrine and tropinone are transported into the cells and the turnover of hygrine is very high. The turnover rate of tropinone is considerably enhanced in cultures fed with both compounds simultaneously, but tropanol, hyoscyamine and scopolamine were consistently undetected in the cell material. Biosynthesis of precursors and alkaloids was repressed in the cultures studied, and the repression could not be reversed by increased intracellular substrate levels.

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