Saccharomyces cerevisiae Polymerase ζ Functions in Mitochondria
- 1 April 2006
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 172 (4) , 2683-2688
- https://doi.org/10.1534/genetics.105.051029
Abstract
The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase ζ and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase ζ and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase ζ and Rev1 proteins function in the mitochondria.Keywords
This publication has 38 references indexed in Scilit:
- Targeting of O6-MeG DNA methyltransferase (MGMT) to mitochondria protects against alkylation induced cell deathMitochondrion, 2005
- Rev1 Employs a Novel Mechanism of DNA Synthesis Using a Protein TemplateScience, 2005
- The Common A467T Mutation in the Human Mitochondrial DNA Polymerase (POLG) Compromises Catalytic Efficiency and Interaction with the Accessory SubunitJournal of Biological Chemistry, 2005
- Oxidative DNA Damage Causes Mitochondrial Genomic Instability in Saccharomyces cerevisiaeMolecular and Cellular Biology, 2005
- The property of DNA polymerase ζ: REV7 is a putative protein involved in translesion DNA synthesis and cell cycle controlMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2002
- Interactions in the Error-prone Postreplication Repair Proteins hREV1, hREV3, and hREV7Journal of Biological Chemistry, 2001
- A Human REV7 Homolog That Interacts with the Polymerase ζ Catalytic Subunit hREV3 and the Spindle Assembly Checkpoint Protein hMAD2Journal of Biological Chemistry, 2000
- Repair of mtDNA in VertebratesAmerican Journal of Human Genetics, 1999
- Import of proteins into mitochondria and chloroplastsTrends in Cell Biology, 1997
- Deoxycytidyl transferase activity of yeast REV1 proteinNature, 1996