Functional Modulation of Escherichia Coli RNA Polymerase
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- 1 October 2000
- journal article
- review article
- Published by Annual Reviews in Annual Review of Microbiology
- Vol. 54 (1) , 499-518
- https://doi.org/10.1146/annurev.micro.54.1.499
Abstract
▪ Abstract The promoter recognition specificity of Escherichia coli RNA polymerase is modulated by replacement of the σ subunit in the first step and by interaction with transcription factors in the second step. The overall differentiated state of ∼2000 molecules of the RNA polymerase in a single cell can be estimated after measurement of both the intracellular concentrations and the RNA polymerase-binding affinities for all seven species of the σ subunit and 100–150 transcription factors. The anticipated impact from this line of systematic approach is that the prediction of the expression hierarchy of ∼4000 genes on the E. coli genome can be estimated.Keywords
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