High-resolution autoradiographic localization of 3-methylcholanthrene-3H in the skin of Balb/c mice after topical application

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Abstract
Tritiated 3-methylcholanthrene (MC) was traced by EM autoradiography in Balb/c mouse epidermis 24 h after topical application in vivo. Quantification of the autoradiographs indicated that the distribution of radioactivity was non-random. The frequency of Ag grains was similar in both nuclei and cytoplasm of epidermal cells. A concentration of labeling was detected in association with nuclear and cell membranes but to a greater degree with the dromo-epidermal junction. Results were consistent with previous work on the binding of hydrocarbons to soluble proteins and nucleic acids. The significance of the association of radioactivity with the dermo-epidermal junction was discussed.

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