Inositol 1,4,5‐trisphosphate may be a signal for f‐Met‐Leu‐Phe‐induced intracellular Ca mobilisation in human leucocytes (HL‐60 cells)
- 15 October 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 176 (1) , 193-196
- https://doi.org/10.1016/0014-5793(84)80939-4
Abstract
Pemeabilised, dimethyl sulphoxide‐differentiated HL‐60 human myelomonocytic leukemia cells accumulate 45Ca in an ATP‐dependent manner. The 45Ca is taken up by a pool thought to be a component of the endoplasmic reticulum. Inositol trisphosphate induced a rapid release of Ca from this pool, suggesting that this molecule which is formed in these cells in response to f‐Met‐Leu‐Phe may play a role in agonist‐induced Ca metabolism.Keywords
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