Can cell systems biology rescue drug discovery?
- 24 May 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 4 (6) , 461-467
- https://doi.org/10.1038/nrd1754
Abstract
The focus of innovation in current drug discovery is on new targets, yet compound efficacy and safety in biological models of disease - not target selection - are the criteria that determine which drug candidates enter the clinic. We consider a biology-driven approach to drug discovery that involves screening compounds by automated response profiling in disease models based on complex human-cell systems. Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development.Keywords
This publication has 21 references indexed in Scilit:
- Systems biology in drug discoveryNature Biotechnology, 2004
- Target validationCurrent Opinion in Pharmacology, 2003
- Drug research: myths, hype and realityNature Reviews Drug Discovery, 2003
- Strategic trends in the drug industryDrug Discovery Today, 2003
- The price of innovation: new estimates of drug development costsJournal of Health Economics, 2003
- Modern biomedical research: an internally self-consistent universe with little contact with medical reality?Nature Reviews Drug Discovery, 2003
- Knockouts model the 100 best-selling drugs—will they model the next 100?Nature Reviews Drug Discovery, 2003
- The druggable genomeNature Reviews Drug Discovery, 2002
- Value of novelty?Nature Reviews Drug Discovery, 2002
- Realism in drug discovery—could Cassandra be right?Nature Biotechnology, 2001