DEPRESSION OF GASTRIC SECRETION BY THE ANTERIOR PITUITARY-LIKE FRACTION OF PREGNANCY URINE1,2

Abstract
A study of the effect of the parenteral adm. of the APL fraction of human pregnancy urine on the gastric secretory response to a test meal was made in 5 [female] dogs with Pavlov pouches. After suitable control tests, 1000-2000 R.U. of antuitrin-S and 5000 U. of follutein were given parenterally 1/2 hr. before the test meal. In 4 of the 5 dogs, in 7 out of 8 tests, significant to marked decreases in volume and acid output occurred each day during a 5-day period of treatment. In 4 of 7 instances the secretory response returned to normal one day after cessation of treatment; in the other 3, return was slower.

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