The arsonomethyl analogue of 3-phosphoglycerate

Abstract
4-Arsono-2-hydroxybutanoic acid, the analog of 3-phosphoglycerate in which.sbd.CH2.sbd.AsO3H2 replaces.sbd.O.sbd.PO3H2, was synthesized. It proved to be a substrate for phosphoglycerate kinase. Its Km was only slightly higher than that of the natural substrate, but its catalytic constant was .apprx. 1300 times smaller.