Interactions of pathogenic Neisseria with host cells. Is it possible to assemble the puzzle?
- 1 June 1999
- journal article
- review article
- Published by Wiley in Molecular Microbiology
- Vol. 32 (6) , 1124-1132
- https://doi.org/10.1046/j.1365-2958.1999.01416.x
Abstract
Neisseria meningitidis and Neisseria gonorrhoeae are human pathogens that have to interact with mucosa and/or cellular barriers for their life cycles to progress. Even though they both give rise to dramatically different diseases, the use of in vitro models has shown that most of the mechanisms mediating cellular interactions are common to N. meningitidis and N. gonorrhoeae. This suggests that bacterial cell interactions may be essential not only for pathogenesis but also for other aspects of the bacterial life cycle that are common to both N. meningitidis and N. gonorrhoeae. This manuscript will review the most recent developments concerning the mechanisms mediating cellular interaction of pathogenic Neisseria and will then try to put them into the perspective of pathogenesis and bacterial life cycle.Keywords
This publication has 70 references indexed in Scilit:
- Vitronectin‐dependent invasion of epithelial cells by Neisseria gonorrhoeae involves αv integrin receptorsFEBS Letters, 1998
- Differential Opa specificities for CD66 receptors influence tissue interactions and cellular response to Neisseria gonorrhoeaeMolecular Microbiology, 1997
- Neisseria gonorrhoeae Epithelial Cell Interaction Leads to the Activation of the Transcription Factors Nuclear Factor κB and Activator Protein 1 and the Induction of Inflammatory CytokinesThe Journal of Experimental Medicine, 1997
- Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic neisseriaeMolecular Microbiology, 1996
- Variable expression of the Opc outer membrane protein in Neisseria meningitidis is caused by size variation of a promoter containing poly‐cytidineMolecular Microbiology, 1994
- Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.The Journal of Experimental Medicine, 1994
- Meningococcal Opa and Opc proteins: their role in colonization and invasion of human epithelial and endothelial cellsMolecular Microbiology, 1993
- Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidisMolecular Microbiology, 1992
- Expression of outer membrane protein II by gonococci in experimental gonorrhea.The Journal of Experimental Medicine, 1988
- Mechanisms of Mucosal Invasion by Pathogenic NeisseriaClinical Infectious Diseases, 1983