Synthetic Studies on Echinulin and Related Natural Products. I. : Acid-Catalyzed Amino-Claisen Rearrangement of N-Allylaniline and N, N-Diallylaniline Derivatives

Abstract
In connection with a total synthesis of echinulin [Aspergillus echinulatus] and related alkaloids, acid-catalyzed amino-Claisen rearrangement of N-allylaniline, N,2-diallylaniline, N,2,6-triallylaniline and N,N-diallylaniline was examined in refluxing xylene, in the presence of zinc chloride or boron trifluoride etherate. Boron trifluoride etherate was found to be a more effective acid for this rearrangement.

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