Dose Dependence of N‐Hydroxy‐3,2′‐dimethyM‐aminobiphenyl‐induced Rat Prostate Carcinogenesis
Open Access
- 1 July 1992
- journal article
- research article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 83 (7) , 695-698
- https://doi.org/10.1111/j.1349-7006.1992.tb01968.x
Abstract
Groups of F344 rats were administered biweekly intraperitoneal injections of N‐hydroxy‐3,2′‐dimethyl‐4‐aminobiphenyl (N‐OH‐DMAB) at a dose of 5, 10 or 20 mg/kg body weight or DMAB, the parent compound, at a dose of 25 mg/kg body weight, for a total of 10 times. Prostate carcinomas in the ventral lobe developed in a N‐OH‐DMAB dose‐dependent manner (0, 17.6 and 66.7%, respectively) with limited tumor yields in other organs. Although intraperitoneal administration of DMAB was similarly found to induce prostate tumors, it also caused severe chemical peritonitis, which resulted in a high mortality. The present data confirmed that intraperitoneal administration of N‐OH‐DMAB provides a relatively specific induction method for models of prostate carcinogenesis.Keywords
This publication has 7 references indexed in Scilit:
- Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate.1991
- Selective Induction of Prostate Carcinomas in F344 Rats Treated with Intraperitoneal Injections of N‐Hydroxy‐3,2′‐dimethyl‐4‐aminobiphenylJapanese Journal of Cancer Research, 1990
- VARIATION IN TUMOR YIELD IN THE PROSTATE AND OTHER TARGET ORGANS OF THE RAT IN RESPONSE TO VARIED DOSAGE AND DURATION OF ADMINISTRATION OF 3,2'-DIMETHYL-4-AMINOBIPHENYL1988
- INDUCTION OF PROSTATE CARCINOMA INSITU AT HIGH-INCIDENCE IN F344 RATS BY A COMBINATION OF 3,2'-DIMETHYL-4-AMINOBIPHENYL AND ETHINYL ESTRADIOL1986
- RAT PROSTATE AS ONE OF THE TARGET ORGANS FOR 3,2'-DIMETHYL-4-AMINOBIPHENYL-INDUCED CARCINOGENESIS - EFFECTS OF DIETARY ETHINYL ESTRADIOL AND METHYLTESTOSTERONE1985
- Adenocarcinomas of the prostate induced by N-nitroso-N-methylurea in rats pretreated with cyproterone acetate and testosteroneCancer Letters, 1983
- Structure-mutagenicity relationships of N-oxidized derivatives of aniline, o-toluidine, 2'-methyl-4-aminobiphenyl, and 3,2'-dimethyl-4-aminobiphenylJournal of Medicinal Chemistry, 1979