Effect of a Uridine 5′-Diphosphate Glucose Analogue, on Herpes simplex keratitis in Rabbits and Vaginal Infection, in Guinea Pigs

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Abstract
A uridine 5''-diphosphate glucose analogue, active in vitro against herpes simplex type 1 and 2 viruses, was assayed in rabbit infected corneas with the above viruses. The infected eyes were treated by drug instillation thrice daily and evalatuion of ocular lesion was performed by slit-lamp biomicroscopy. The compound [({[5''-(2",3",4",6"-tetra-O-benzoyl-.alpha.-D-glucopyranosyl)oxy]carbonyl}amino) sulfonyl]uridine shows a moderate antiviral activity, resulting in a reduction in the severity of clinical illness during acute infection. Vaginal infection of guinea pigs with herpes simplex type 2 virus was treated topically by instillation twice daily with the compound. The effect on clinical evolution was related to viral shedding from the genital tract, and a moderate reduction of both parameters in respect to the infected untreated controls was observed.