Anatomy and Physiology of Intrarenal Oxygen Tension

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Abstract
Urinary O2 tension may indicate changing conditions in the medulla. This study, which tests this hypothesis and tries to promote understanding of intrarenal hemodynamics concluded that: renal parenchymal O2 tension depends upon regional blood flow, local consumption of O2 and activity of the countercurrent mechanism; the latter is not only confined to the medulla but is operative in the cortex; urinary O2 tension equals the mean medullary PO2 regardless of the inspired O2 concentration or the anesthetic agent; a standard procedure for continuous or serial PO2 determination in the urine appears suitable for the study of medullary perfusion and countercurrent activity; this procedure may be more sensitive than other tests in determining the effects of anesthetic agents.

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