Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors

8 May 2002

journal article
research article
Published by Springer Nature in Diabetologia

Vol. 45 (6) , 805-812
https://doi.org/10.1007/s00125-002-0829-2

Abstract

Aims/hypothesis. A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance. Methods. A total of 1653 individuals aged 55 to 74 years participated in a population based survey in Southern Germany (KORA Survey 2000). Those without a history of diabetes were subjected to an OGTT. Randomly selected subjects with IGT (n=80) were compared with non-diabetic control subjects (n=77) and patients with Type II diabetes (n=152) of the same population-based sample after matching for age and sex. Immune parameters were analysed in serum with rigidly evaluated ELISA. Results. Serum pro-inflammatory cytokine interleukin 6 (IL-6) concentrations were higher in subjects with IGT and Type II diabetes than in the control subjects (median 1.8 and 2.5 vs 0.8 pg/ml, ppConclusion/interpretation. Our study shows systemic up-regulation of selected inflammatory mediators in patients with Type II diabetes and IGT. The pattern observed is non-random and fits with an IL-6 associated rather than TNF-α associated response.

Keywords

TYPE II DIABETES IMPAIRED GLUCOSE TOLERANCE SYSTEMIC INFLAMMATION INTERLEUKIN 6 TUMOUR NECROSIS FACTOR Α C-REACTIVE PROTEIN SERUM AMYLOID A PROTEIN INNATE IMMUNITY CYTOKINE ACUTE-PHASE PROTEIN

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