Action of methylcellulose on disintegration and dissolution properties of tablets.

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Abstract
The action of methylcellulose (MC) of different vicosity on the properties of tablets was studied. The penetration of water into the tablets was retarded by the presence of MC. The disintegration time of tablets was reduced with increasing viscosity of MC and a high level of starch. This correlates with the water penetration data. Dissolution of tablets is governed to a lesser extent by water uptake into the tablets. It is more influenced by the gel formed by MC and the diffusion of drug through this layer. With higher concentration of methylcellulose the adhesiveness of MC becomes more significant in decreasing dissolution of the tablets. MC in contact with water hydrates, swells, gels and becomes adhesive. These actions are affected by starch, MC concentration and viscosity.

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