Acute Zinc Deficiency in Man during Intravenous Alimentation1

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Abstract
Changes in the plasma levels and urinary excretion of sine have been studied in a series of adult patients receiving intravenous alimentation. Urinary sine loss may be very high in this group, but serious plasma depletion does not occur unless there is a concomitant phase of sustained anabolism in the absence of significant exogenous intake. A syndrome of acute sine deficiency is described consisting of diarrha?a, mental apathy and depression, a moist ecsematoid dermatitis, most severe in the perioral area, and alopecia. The response to intravenous sine therapy is very striking, although alopecia is slower to develop and complete hair regrowth is correspondingly delayed.

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