High frequency of c-K-ras activation in 3-methylcholanthrene-induced mouse thymomas
- 1 November 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 7 (11) , 1931-1933
- https://doi.org/10.1093/carcin/7.11.1931
Abstract
Thymic lymphomas were induced in RJF mice by percutaneous application of 3-methykholanthrene (MCA). DNAs from 83% of the tumors analyzed contained a transforming c-K-ras gene. The high frequency of c-K- ras oncogene activation in response to MCA seems to favor the concept that the activation of c-K- ras is related to the specificity of the mutagenic effect of MCA.This publication has 10 references indexed in Scilit:
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