Mechanism of Release from Mast Cells

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Abstract
Polymer amines (such as compound 48/80), principles extracted from biologic material (such as Ascaris suis and Cyanea capillata) and antigens (such as albumin) cause morphologic changes in isolated rat mast cells and release histamine and serotonin from such cells. The influence of pH, ionic milieu, temperature and enzyme inhibitors indicate the participation of enzymatic mechanisms in these processes. The influence of metabolic inhibitors, oxygen, and glucose suggest that the mast cell processes require energy. The hypothesis is advanced that the morphologic changes reflect a process whereby histamine- and serotonin- carrying granules pass to the mast cell surface where they relinquish their amines. "SRS" (slow reacting substance, a smooth muscle stimulating principle) is formed in the mast cell during the release process.

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