Laminar shear stress acts as a switch to regulate divergent functions of NF‐κB in endothelial cells
Open Access
- 8 June 2007
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 21 (13) , 3553-3561
- https://doi.org/10.1096/fj.06-8059com
Abstract
Regions of the arterial tree exposed to laminar flow, which exerts high shear stress, are protected from inflammation, endothelial cell (EC) death and atherosclerosis. TNFα activates NF-κB transcript...Keywords
Funding Information
- British Heart Foundation
This publication has 41 references indexed in Scilit:
- Chromatin Modification and the Endothelial-specific Activation of the E-selectin GeneJournal of Biological Chemistry, 2005
- Inflammation in atherosclerosisNature, 2002
- Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signallingNature, 2001
- Adhesion molecules and atherogenesisActa Physiologica Scandinavica, 2001
- A1 Functions at the Mitochondria to Delay Endothelial Apoptosis in Response to Tumor Necrosis FactorJournal of Biological Chemistry, 2000
- The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosisGenes & Development, 1999
- A Sustained Reduction in IκB-β May Contribute to Persistent NF-κB Activation in Human Endothelial CellsJournal of Biological Chemistry, 1996
- NF-kappa B subunit-specific regulation of the interleukin-8 promoter.Molecular and Cellular Biology, 1993
- Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells.Molecular and Cellular Biology, 1993
- Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factorCell, 1989