Familial aggregation of lipids and lipoproteins in families identified through random and nonrandom probands in the Oklahoma Lipid Research Clinic Family Study

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Abstract
Familial aggregation of cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was investigated in families identified through both random and nonrandom probands in the Oklahoma Lipid Research Clinic Family Study. Nonrandom proband identification was based on single selection through truncation for elevated lipid levels at an earlier screening. A path model was used to investigate the nature of familial resemblance for the lipids and lipoproteins using appropriate adjustments for ascertainment. Results generally indicate that there is substantial genetic heritability for all phenotypes, with the highest estimates for cholesterol, lowest for triglycerides, and intermediate for high-density lipoprotein cholesterol and low-density lipoprotein cholesterol. Common family environmental effects are modest, and possibly near zero for cholesterol and low-density lipoprotein cholesterol. There are no spouse correlations, modest cultural transmission with no maternal effects, and inconsistent evidence of sibship nontransmitted environmental resemblance.

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