Effects of 4‐aminopyridine on Statistical Parameters of Transmitter Release at the Neuromuscular Junction
- 1 May 1979
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 44 (5) , 343-346
- https://doi.org/10.1111/j.1600-0773.1979.tb02341.x
Abstract
4-Aminopyridine (4-AP) potentiates transmitter release from motor nerve terminals [rat extensor digitorum longus muscle and frog (Rana temporaria) sartorius muscle] by increasing the quantum content (m) of endplate potentials [epp]. Estimates of the binomial parameters of transmitter release shows that 4-AP enhances m by increasing n [the store of transmitter available for release] and not p [the probability of release of available transmitter quanta].Keywords
This publication has 28 references indexed in Scilit:
- Effects of 4-aminopyridine in myasthenia gravis.Journal of Neurology, Neurosurgery & Psychiatry, 1979
- Effects of 4-aminopyridine on neuromuscular transmissionBrain Research, 1978
- Transmitter release statistics are meaningfulNature, 1978
- Effects of 4-aminopyridine on mechanical activity and noradrenaline release in the rat portal vein in vitroEuropean Journal of Pharmacology, 1977
- Effects of 4-aminopyridine on transmission in excitatory and inhibitory synapses in the spinal cordBrain Research, 1977
- Short report: 4-Aminopyridine--a new drug tested in the treatment of Eaton-Lambert syndromeJournal of Neurology, Neurosurgery & Psychiatry, 1977
- Are transmitter release statistics meaningful?Nature, 1977
- Antagonism of the paralysis produced by botulinum toxin in the ratJournal of the Neurological Sciences, 1977
- The mode of action of 4-aminopyridine and guanidine on transmitter release from motor nerve terminalsEuropean Journal of Pharmacology, 1977
- Evoked neurotransmitter release: statistical effects of nonuniformity and nonstationarity.Proceedings of the National Academy of Sciences, 1976