Inactivation of Long-Acting Thyroid Stimulator (LATS) by Anti-kappa and Anti-lambda Antisera1
- 1 October 1968
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 28 (10) , 1440-1444
- https://doi.org/10.1210/jcem-28-10-1440
Abstract
Tests were made of the ability of specific antisera against kappa- and lambda-type B chains of human immunoglobulin to inactivate the biologic activity of 7 different sera containing long-acting thyroid stimulator (LATS) globulin. In each instance serum LATS activity was inactivated partly by anti-kappa and partly by anti-lambda/antiserum, and the combined inactivation by both antisera approximated 100%. The findings are interpreted as showing that LATS globulin is not the product of a cell line derived by a monoclonal selection process. In addition, the results add further evidence confirming the immunoglobulin nature of LATS.Keywords
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