DNA indels in coding regions reveal selective constraints on protein evolution in the human lineage
Open Access
- 1 January 2007
- journal article
- Published by Springer Nature in BMC Ecology and Evolution
- Vol. 7 (1) , 191
- https://doi.org/10.1186/1471-2148-7-191
Abstract
Insertions and deletions of DNA segments (indels) are together with substitutions the major mutational processes that generate genetic variation. Here we focus on recent DNA insertions and deletions in protein coding regions of the human genome to investigate selective constraints on indels in protein evolution.Keywords
This publication has 27 references indexed in Scilit:
- The Majority of Recent Short DNA Insertions in the Human Genome Are Tandem DuplicationsMolecular Biology and Evolution, 2007
- Human-specific insertions and deletions inferred from mammalian genome sequencesGenome Research, 2006
- Estimation of Amino Acid Residue Substitution Rates at Local Spatial Regions and Application in Protein Function Inference: A Bayesian Monte Carlo ApproachMolecular Biology and Evolution, 2005
- Initial sequence of the chimpanzee genome and comparison with the human genomeNature, 2005
- Sequence Turnover and Tandem Repeats in cis-Regulatory Modules in DrosophilaMolecular Biology and Evolution, 2005
- DNA sequence and comparative analysis of chimpanzee chromosome 22Nature, 2004
- Occurrence and Consequences of Coding Sequence Insertions and Deletions in Mammalian GenomesGenome Research, 2004
- Majority of divergence between closely related DNA samples is due to indelsProceedings of the National Academy of Sciences, 2003
- Genomic Divergences between Humans and Other Hominoids and the Effective Population Size of the Common Ancestor of Humans and ChimpanzeesAmerican Journal of Human Genetics, 2001
- Environment‐specific amino acid substitution tables: Tertiary templates and prediction of protein foldsProtein Science, 1992