The effect of phalloidin on insulin secretion from islets of langerhans isolated from rat pancreas
- 1 October 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 175 (2) , 393-396
- https://doi.org/10.1016/0014-5793(84)80775-9
Abstract
Phalloidin, which stabilizes F‐actin, has no effect on insulin secretion from intact islets, but penetrates and increases secretion from islets previously made permeable using a high voltage discharge technique. Use of this highly specific drug strongly suggests a role for microfilaments composed of F‐actin in the insulin secretory process.Keywords
This publication has 16 references indexed in Scilit:
- The mechanism of insulin secretionDiabetologia, 1984
- Regulation of insulin secretion from islets of Langerhans rendered permeable by electric dischargeBiochemical Journal, 1982
- Dynamics of Insulin Release and Microtubular-Microfilamentous System. VI. Effect of D2OEndocrinology, 1974
- Effect of Cytochalasin B on the Biphasic Release of Insulin in Perifused Rat IsletsEndocrinology, 1973
- Perifusion of Isolated Rat Islets in Vitro: Participation of the Microtubular System in the Biphasic Release of InsulinDiabetes, 1972
- Mathematical theory of cross-reactive radioimmunoassay and ligand-binding systems at equilibriumAnalytical Biochemistry, 1972
- Use of Polyethylene Glycol to Separate Free and Antibody-Bound Peptide Hormones in Radioimmunoassays†Journal of Clinical Endocrinology & Metabolism, 1971
- New Hypothesis of Insulin SecretionNature, 1968
- Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific ActivityNature, 1962
- The Maintenance of Human Normal Cells and Tumor Cells in Continuous Culture: I. Preliminary Report: Cultivation of Mesoblastic Tumors and Normal Tissue and Notes on Methods of CultivationThe American Journal of Cancer, 1936