Macrocyclic polyamines as calculi solubilizers.

1 January 1983

journal article
research article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 31 (9) , 3264-3268
https://doi.org/10.1248/cpb.31.3264

Abstract

The novel complexing properties of macrocyclic polyamines with phosphate and oxalate anions were tested against urinary calculi. An 18-membered hexaamine [18]ane N6 and a 16-membered pentaamine [16]ane N5 in vitro solubilized inorganic models of calculi (Ca3(PO4)2 and Ca(C2O4)) and human urinary calculi in acidic solutions, implying that they may be useful as a new type of ingredient of irrigating fluids.

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