Metabolism and excretion of orally and intraperitoneally administered trimethylarsine oxide in the hamster
- 15 May 1989
- journal article
- research article
- Published by Taylor & Francis in Toxicological & Environmental Chemistry
- Vol. 22 (1) , 69-76
- https://doi.org/10.1080/02772248909357425
Abstract
When trimethylarsine oxide (TMAO) was administered orally to hamsters once only, 86.9±11.1% of the administered dose of the compound was exreted in the urine during the following 24 hours: TMAO proved to be an arsenic compound eliminated extremely rapidly. The unchanged form of TMAO was the one and only trimethylarsenic compound (TMA) detected in the urine: in othe words, TMAO proved neither to be demethylated nor to be converted to arsenobetaine. It was shown, on the other hand, that TMAO is partly reduced in vivo and that only trimethylarsine was detected in expired air.Keywords
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