Nonhuman Primates: A Critical Role in Current Disease Research
Open Access
- 1 January 2001
- journal article
- review article
- Published by Oxford University Press (OUP) in ILAR Journal
- Vol. 42 (2) , 74-84
- https://doi.org/10.1093/ilar.42.2.74
Abstract
This review article emphasizes the critical role of nonhuman primates (NHPs) in biomedical research. It focuses on the most recent contributions that NHPs have made to the understanding, treatment, and prevention of important infectious diseases (e.g., acquired immunodeficiency syndrome, hepatitis, malaria) and chronic degenerative disorders of the central nervous system (e.g., Parkinson’s and Alzheimer’s diseases). The close phylogenetic relation of NHPs to humans not only opens avenues for testing the safety and efficacy of new drugs and vaccines but also offers promise for evaluating the potential of new gene-based treatments for human infectious and genetic diseases.Keywords
This publication has 92 references indexed in Scilit:
- The Outcome of Acute Hepatitis C Predicted by the Evolution of the Viral QuasispeciesScience, 2000
- The ?2-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances anti-parkinsonian actions ofL-dopa in the MPTP-lesioned primate model of Parkinson's diseaseMovement Disorders, 1999
- Viral Clearance Without Destruction of Infected Cells During Acute HBV InfectionScience, 1999
- Researchers Urged Not to Inject Virulent HIV Strain Into ChimpsScience, 1999
- The live attenuated subgroup B respiratory syncytial virus vaccine candidate RSV 2B33F is attenuated and immunogenic in chimpanzees, but exhibits partial loss of the ts phenotype following replication in vivoVirus Research, 1999
- In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vectorGene Therapy, 1998
- Characteristics of systemic antibody responses of nonhuman primates following active immunization with Porphyromonas gingivalis, Prevotella intermedia and Bacteroides fragilisOral Microbiology and Immunology, 1996
- Cell envelope and cell wall immunization of Macaca fascicularis:. effect on the progression of ligature‐induced periodontitisOral Microbiology and Immunology, 1995
- An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccinesVirus Research, 1994
- AIDSChoice Reviews Online, 1991