Oxalate Metabolism and Renal Calculi

Publisher Website
Google Scholar
Abstract
Accumulating evidence suggests a relationship between mild hyperoxaluria and idiopathic calcium oxalate renal lithiasis [in humans]. Levels of urinary oxalate are significantly higher in patients with active stone disease than in normals or in patients in whom stone disease is inactive. Changes in urinary oxalate concentration are 15 times as potent as changes in Ca concentration in altering the saturation of urine with calcium oxalate. Decreasing oxalate excretion is apparently the most important factor in decreasing the risk of new stone formation in patients with calculous disease. A review of the knowledge about intestinal absorption, endogenous production and excretion of oxalate may be pertinent.