Closed circular viral DNA and asymmetrical heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus
- 1 October 1983
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 48 (1) , 1-9
- https://doi.org/10.1128/jvi.48.1.1-9.1983
Abstract
To identify possible intermediates in the replication of ground squirrel hepatitis virus, major forms of intracelluar virus-specific DNA in the livers of infected ground squirrels were characterized. A variety of DNA species were found: covalently closed circular molecules, relaxed circular molecules and a heterogeneous collection of molecules that migrated ahead of closed circuit DNA during agarose gel electrophoresis. The heterogeneous DNA was at least partly single stranded, consisted of minus strands in a > 8-fold mass excess of plus strands and was tightly associated with protein.This publication has 26 references indexed in Scilit:
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